Resources
Learn how to use our products with step-by-step instructions and downloadable resources. Select a product below to get started.








Verruca-Freeze®
Downloadable Resources
Instructions for Use
Post-Treatment Care
Freeze Time Chart
Instructional Video
Before getting started, be sure to watch our training video for the most comprehensive understanding of the procedure.
Prior to Initial Use
Inspect all product components for any signs of damage prior to initial use. If any component is damaged or appears defective, do not use. Instead, contact CryoSurgery to report the issue and request a replacement.
STEP 1: Remove safety tab from the top of the canister nozzle.
STEP 2: Firmly insert the clear extender tube into the round opening on the trigger nozzle.
STEP 3: Perform a test spray to ensure the canister is in working order.
Applicator Selection
Select an application method based on lesion location and tissue type. Use an applicator that is approximately 1mm larger in size than the lesion to be treated.

CryoBud® Applicators
Available Sizes: 3, 5, 9mm
Recommended for use on:
- Bony or hard-to-reach areas
- Sensitive or thin skin, including the face, neck, head, and genitals
- Hands and feet
- Pediatric patients
TIP: Medium and large buds will hold freeze charge for 90–120 seconds, allowing for treatment of multiple lesions without additional saturation.

CryoCone® Applicators
Available Sizes: 3, 5, 7, 9, 12mm
Recommended for use on:
- Fleshy or fatty tissue, such as the abdomen, back, or thighs
- Areas where a tight, consistent seal can be achieved.
Do not use cones on bony areas, as achieving a proper seal is difficult and can lead to cryogen leakage and damage to surrounding tissue.
TIP: 12mm cone may be inverted to treat lesions up to 25mm.
CryoBud® Treatment
Note: CryoBud® applicators are not to be used on more than one patient. Dispose after treatment is complete.
STEP 1: Firmly insert the clear extender tube into the round opening on the trigger nozzle.
STEP 2: Hold plastic end of bud in one hand and canister in the other hand. Ensure the extender tube is positioned about 1cm from the bud’s foam tip.
STEP 3: Lightly spray cryogen for 3–6 seconds or or until the first droplet emerges from the foam tip. Rotate bud during spray to ensure maximum saturation.
STEP 4: Point bud downward and wait approximately 15–20 seconds for the bud to crystallize and reach its optimal freezing temperature of -70°C.

Optional Inserted Method
For one-handed application, remove the clear extender tube and insert the hollow, plastic end of CryoBud® directly into the canister’s trigger nozzle.
If desired, CryoBud® may be removed from canister prior to application to the lesion.
CryoCone® Treatment
Note: CryoCone® applicators are reuseable and must be disinfected after each use on a patient. See downloadable content section above for cleaning instructions.
STEP 1: Firmly insert the clear extender tube into the round opening on the trigger nozzle.
STEP 2: Hold upper ridge of cone in one hand and canister in the other hand.
STEP 3: Place the colored tip of the cone around the lesion and press firmly to create a tight seal. Ensure the cone is perpendicular to the ground for even accumulation of cryogen.
STEP 4: Hold the canister at a 45° angle and position the extender tube about 1cm from the inside wall of the cone. Lightly spray cryogen for 3–6 seconds or until 1/8 to 1/4 inch of accumulation has occurred.
Post-Application
Once the applicator is removed, a concentric white ice ball will appear on the area treated. Allow the ice ball to thaw naturally for a minimum of 40 seconds.
It is important to not touch the treated area until completely thawed as premature warming will reduce the effectiveness of the freeze.
If an ice ball does not appear, the lesion may have been under-frozen. Repeat the steps above to ensure destruction of the entire lesion.
Verruca-Freeze® H
Downloadable Resources
Instructions for Use
Post-Treatment Care
Freeze Time Chart
Instructional Video
Before getting started, be sure to watch our training video for the most comprehensive understanding of the procedure.
Prior to Initial Use
Inspect all product components for any signs of damage prior to initial use. If any component is damaged or appears defective, do not use. Instead, contact CryoSurgery to report the issue and request a replacement.
Applicator Selection
Select an applicator that is approximately 1mm larger in size than the lesion to be treated.

Arrow CryoBud®
Size: 2mm

Round CryoBud®
Size: 5mm
CryoBud® Treatment
Note: CryoBud® applicators are not to be used on more than one patient. Dispose after treatment is complete.
STEP 1: Firmly insert the plastic end of bud into the round opening on the trigger nozzle.
STEP 2: Once the bud is secure, hold the canister upright and remove the safety cap.
STEP 3: Gently press dispensing valve for approximately 3–6 seconds or until the first droplet emerges from the foam tip.
STEP 4: Point bud downward and wait approximately 15–20 seconds for the bud to crystallize and reach its optimal freezing temperature of -55°C.
STEP 5: Place frozen bud directly onto the lesion and hold firmly for recommended freeze time (15–40 seconds based on lesion type).
View Recommended Freeze Time Chart
Do not press dispensing valve while CryoBud® is in contact with skin.
Post-Application
Once the applicator is removed, a concentric white ice ball will appear on the area treated. Allow the ice ball to thaw naturally for a minimum of 40 seconds.
It is important to not touch the treated area until completely thawed as premature warming will reduce the effectiveness of the freeze.
If an ice ball does not appear, the lesion may have been under-frozen. Repeat the steps above to ensure destruction of the entire lesion.
Verruca-Freeze® and Verruca-Freeze® H are FDA-approved Class II Medical Devices authorized for use by licensed medical and veterinary professionals only. An active medical or veterinary license is required for purchase and will be verified by CryoSurgery for authenticity and validity. Sale or other distribution of any Verruca-Freeze® product to patients is strictly prohibited.
CryoSurgery is committed to delivering outstanding customer value, by providing high quality cryosurgical products that consistently meet the needs of our customers, as well as complying with regulatory requirements and maintaining the effectiveness of the our Quality Management System.


