How To Use Verruca-Freeze®

Before getting started, be sure to familiarize yourself with the proper technique.

Two Methods of Application

Select an applicator based on the location of the lesion to be treated and choose a size that is approximately 1mm larger than the lesion.


Use cones for fleshy areas of the body, where a tight seal can be easily achieved, such as the stomach or back.

Available Sizes: 3, 5, 7, 9, 12mm

Tip: Use 12mm CryoCone® upside down to treat larger lesions up to 25mm in size


Use buds for bony or hard-to-reach areas of the body, as well as the head, face, and neck.

Available Sizes: 3, 5, 9mm

Medium and large CryoBuds® will hold freeze charge for 90-120 seconds, so 2-3 lesions can be frozen on the same patient

CryoCone® Method

Position the tip of the cone around the lesion and press firmly to create a seal.

Lightly spray cryogen at a 45° angle against the inside wall of the cone for 3-6 seconds or until 1/8 to 1/4 inch of accumulation has occurred.

Hold cone firmly in place for 20-40 seconds until cryogen has completely evaporated or boiled off.

CryoBud® Method

Lightly spray cryogen for 3-6 seconds or until the bud is saturated to the first drip point. Be sure to rotate the bud while saturating.

Wait approximately 15 seconds for the bud to crystalize and reach maximum freezing temperature of -70° C.

Place the frozen bud directly onto the lesion and hold firmly for 20-40 seconds.

Inserted Method

For one-handed application, CryoBud® may be inserted directly into the nozzle. If using this method, hold canister at a 90° angle with bud pointed downward for optimal saturation.


After a successful treatment, a white iceball should appear. Allow iceball to thaw naturally for approximately 40 seconds and do not touch until completely thawed.

If no ice-ball is visible, the lesion may have been under-frozen. Repeat the steps above to ensure destruction of entire lesion.